Analysis of Clinical Trials


Theme Co-ordinators: Neal Alexander, Baptiste Leurent, Clemence Leyrat, Amy Mulick, Stephen Nash

Please see here for slides and audio recordings of previous seminars relating to this theme.

Randomised controlled trials (RCTs) are one of the most important tools to estimate effects of medical interventions. However, there are a number of issues relating to the statistical analysis of RCTs over which there is much debate. We aim to consider and raise discussion of a number of these issues, and suggest possible statistical approaches for dealing with these in the analyses of RCTs. We briefly introduce here some of these issues.

Topics:

  • Cluster randomised trials
  • Covariate adjustment
  • Subgroup analysis
  • Missing data
  • Non-compliance
  • Sequential trials
  • Good practice in trials