Seminars


For further information on any CSM events please e-mail: csm@lshtm.ac.uk.


Centre for Statistical Methodology Seminar
Friday 28 September 2018, 12:45-2:00pm
LG9, Keppel Street
Assessing comparative effectiveness of cancer treatments in the SEER-Medicare linked database: a causal approach
Lucia Petito (Harvard School of Public Health)

Abstract: Researchers are often interested in evaluating the comparative effectiveness of cancer therapies. Most commonly, these questions are addressed by conducting randomized trials, where the treatment assignment is randomized. However, large randomized trials can be prohibitively expensive or logistically infeasible, so researchers have turned to observational data sources to generate evidence to answer these questions. Unfortunately, naïve analyses of observational data easily lend themselves to misleading and biased results. Here, we will discuss best practices when applying the target trial framework developed by Hernán & Robins (2016) in the SEER-Medicare linked database to emulate randomized trials. We will consider the emulation of two trials: 1) the addition of a drug to a standard chemotherapy regimen to treat metastatic pancreatic cancer, and 2) adjuvant chemotherapy versus observation after tumor resection in individuals with stage II colon cancer.

Hernán, M. A., & Robins, J. M. (2016). Using big data to emulate a target trial when a randomized trial is not available. American journal of epidemiology183(8), 758-764.
Warren, J. L., Klabunde, C. N., Schrag, D., Bach, P. B., & Riley, G. F. (2002). Overview of the SEER-Medicare data: content, research applications, and generalizability to the United States elderly population. Medical care, IV3-IV18.

Centre for Statistical Methodology Seminar
Friday 26 October 2018, 12:45-2:00pm
LG9, Keppel Street
Title TBC
Alexina Mason (LSHTM)

Centre for Statistical Methodology Seminar
Clinical Trials Theme

Friday 2 November 2018, 12:45-2:00pm
LG9, Keppel Street
Title TBC
Sofia Villar (MRC Biostatistics Unit, Cambridge)

Centre for Statistical Methodology Seminar
Clinical Trials Theme

Friday 23 November 2018, 12:45-2:00pm
LG9, Keppel Street
Title TBC
Prof Lucinda Billingham (University of Birmingham)

Centre for Statistical Methodology Seminar
Friday 30 November 2018, 12:45-2:00pm
LG9, Keppel Street
Title TBC
Graham Horgan (Rowett Institute, University of Aberdeen)