The Wellcome Trust and The Royal Society
Sir Henry Dale Fellowship
Statistical methods for studying multidimensional mediators of genetic associations with chronic diseases
5 years (1 Oct 2015 – 30 Sep 2020)
Recent advances in OMICs technology have transformed the nature of biomedical research. Highly-correlated, very high-dimensional biomarker and imaging data are increasingly available in many large prospective datasets such as UK-Biobank. In this fellowship, I will focus on the extension of causal inference methods, particularly mediation analysis with multiple mediators, to these high-dimensional data settings. I plan to apply these methods to address mediation analysis questions in several rich datasets, including the UCLEB consortium of 15 British cohorts with access to 1H-NMR metabolomic data as well as genetic material and incident clinical events (totalling 35K participants with >7K cardiovascular events).