Centre for Statistical Methodology

The Centre for Statistical Methodology aims to gather statistical and methodological expertise across the School in order to strengthen our research capacity in epidemiology and public health.

Welcome to the LSHTM Centre for Statistical Methodology

The LSHTM Centre for Statistical Methodology aims to gather statistical and methodological expertise across the School in order to strengthen our research capacity in epidemiology and public health, and exploit the richness and interdisciplinarity of the work carried out within the School. This is in line with the School’s strategic plans for sustaining areas of established expertise in which we have an international reputation.

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Next CSM Seminar

The Centre hosts regular seminars across the different themes. The next seminar is:

Centre for Statistical Methodology Seminar Clinical Trials Theme Friday 23 November 2018, 12:45-2:00pm LG9, Keppel Street Lessons learned from implementing a stratified medicine master protocol: The National Lung Matrix Trial
Prof Lucinda Billingham (University of Birmingham)

Abstract: The National Lung Matrix Trial (NLMT) is a flagship trial in the United Kingdom being the first to combine the development of a technology platform that screens for multiple genetic aberrations in tumours (provided by the Cancer Research UK Stratified Medicine Programme 2) with testing of multiple novel genetic-marker-directed drugs. The trial is a phase II umbrella-basket trial with an adaptive Bayesian design that tests 7 different drugs targeting 20 molecular markers in patients with advanced non-small cell lung cancer. In addition, patients with no actionable genetic change (NA) are included and will be treated with a sequential pipeline of drugs. Target recruitment for each drug-biomarker cohort is 30 patients to determine whether there is sufficient signal of activity in any drug-biomarker combination to warrant further investigation, with interim analyses after 15 patients. The trial opened to recruitment in March 2015 and is ongoing. This presentation will summarise the clinical, logistical and statistical challenges encountered whilst implementing this master protocol in stratified medicine.

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Recent seminar slides & audio

Slides and audio recordings of many of our previous seminars are available. Our most recent seminars have been:

Clinical Trials Theme
2 November 2018
From Multi-armed Bandits to Response-Adaptive Randomisation: Implementing Optimality Criteria in Clinical Trials
Sofia Villar (MRC Biostatistics Unit, Cambridge)

Clinical Trials Theme
26 October 2018
Framework and practical tool for eliciting expert priors in clinical trials
Alexina Mason (LSHTM)

Causal Inference Theme
28 September 2018
Assessing comparative effectiveness of cancer treatments in the SEER-Medicare linked database: a causal approach
Lucia Petito (Harvard School of Public Health)

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Sequential Trials Symposium

The Centre for Statistical Methodology and the Tropical Epidemiology Group of the London School of Hygiene & Tropical Medicine held a half day symposium on sequential trials on the afternoon of 26 September 2018.

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"Statistical Methods for Big Data” Symposium

The Centre for Statistical Methodology held a half-day symposium on Statistical Methods for Big Data on 7 July 2017. The symposium aimed to discuss features of Big Data and the challenges that they pose for statistical methods and future directions of research. Speakers from different methodological perspectives presented examples across a wide spectrum of applications.

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